COVID Human Challenge Study BOMBSHELLS: Incubation Just 2 Days, Half Never Get Infected
Why did we have to wait 2 years for this???
Editor’s note: Since incubation is just 2 days all those 7, 10, or 14-day quarantines of contacts and international arrivals were absolute garbage.
Also with only half of the participants, none of whom had antibodies, becoming infected after a droplet of virus was literally dropped into their nose, it means contact with virus isn’t sufficient for infection. There are other requirements we know nothing about.
With all these “science” people around, why did it take 2 years for them to finally do some science? Why wasn’t this done and published 2 years ago? Because it would have killed their grift? Because propaganda and playing Stalins is way more fun?
Also this is from Imperial College, the biggest COVID exaggarators and freaks in the world.
Findings from the UK’s world-leading human challenge study provide new insights into mild infections with SARS-CoV-2 in healthy young adults.
The collaborative study is the first in the world to perform detailed monitoring over the full course of COVID-19, from the moment a person first encounters SARS-CoV-2, throughout the infection to the point at which the virus is apparently eliminated.
The Human Challenge Programme is a partnership between Imperial College London, the Vaccine Taskforce and Department of Health and Social Care (DHSC), hVIVO (part of Open Orphan plc.), and the Royal Free London NHS Foundation Trust.
Among several key clinical insights, researchers found that symptoms start to develop very fast, on average about two days after contact with the virus. The infection first appears in the throat; infectious virus peaks about five days into infection and, at that stage, is significantly more abundant in the nose than the throat.
They also found that lateral flow tests (LFTs) are a reassuringly reliable indicator of whether infectious virus is present (i.e., whether they are a likely to be able to transmit virus to other people).
The findings, published on a pre-print server and which have not yet been peer-reviewed, detail the outcomes in 36 healthy, young participants with no immunity to the virus.
This landmark study, which took place at a specialist unit at the Royal Free Hospital in London, shows that experimental infection of volunteers is reproducible and resulted in no severe symptoms in healthy young adult participants, laying the groundwork for future studies to test new vaccines and medicines against COVID-19.
Professor Christopher Chiu, from the Department of Infectious Disease and the Institute of Infection at Imperial College London and Chief Investigator on the trial, said: “First and foremost, there were no severe symptoms or clinical concerns in our challenge infection model of healthy young adult participants.
“People in this age group are believed to be major drivers of the pandemic and these studies, which are representative of mild infection, allow detailed investigation of the factors responsible for infection and pandemic spread.
“Our study reveals some very interesting clinical insights, particularly around the short incubation period of the virus, extremely high viral shedding from the nose, as well as the utility of lateral flow tests, with potential implications for public health.”
In the trial, 36 healthy male and female volunteers aged 18-30 years, unvaccinated against COVID-19 and with no prior infection with SARS-CoV-2 were given a low dose of the virus – introduced via drops up the nose – and then carefully monitored by clinical staff in a controlled environment over a two-week period. The study used virus from very early in the pandemic obtained from a hospitalized patient in the ISARIC4C study, prior to the emergence of the Alpha variant.
Eighteen of the volunteers became infected, 16 of whom went on to develop mild-to-moderate cold-like symptoms, including a stuffy or runny nose, sneezing, and a sore throat. Some experienced headaches, muscle/joint aches, tiredness and fever.
None developed serious symptoms. Two participants were excluded from the final analysis after developing antibodies between initial screening and inoculation.
Thirteen infected volunteers reported temporarily losing their sense of smell (anosmia), but this returned to normal within 90 days in all but three participants – the remainder continue to show improvement after three months.
There were no changes seen in their lungs, or any serious adverse events in any participant. All participants will be followed up for 12 months after leaving the clinical facility to monitor for any potential long-term effects.
Participants were exposed to the lowest possible dose of virus found to cause infection, roughly equivalent to the amount found in a single droplet of nasal fluid when participants were at their most infectious.
Accurate timeline of infection
The study has also revealed some unique insights into the timeline of COVID-19, particularly during the very early period after virus exposure that cannot be looked at in other types of study, where patients are not identified until symptoms are noticed.
Among the 18 infected participants, the average time from first exposure to the virus to viral detection and early symptoms (incubation period) was 42 hours, significantly shorter than existing estimates, which put the average incubation period at 5-6 days.
Following this period there was a steep rise in the amount of virus (viral load) found in swabs taken from participants’ nose or throat.
These levels peaked at around five days into infection on average, but high levels of viable (infectious) virus were still picked up in lab tests up to nine days after inoculation on average, and up to a maximum of 12 days for some, supporting the isolation periods advocated in most guidelines.
There were also differences in where the most virus was found. While the virus was detected first in the throat, significantly earlier than in the nose (40 hours in the throat compared to 58 hours in the nose), levels were lower and peaked sooner in the throat.
Peak levels of virus were significantly higher in the nose than in the throat, indicating a potentially greater risk of virus being shed from the nose than the mouth. This highlights the importance of proper facemask use to cover both the mouth and nose.
Lateral flow tests
Importantly, lateral flow tests (LFTs) were shown to be a good indicator of whether someone was harbouring viable virus. Positive LFTs correlated well with lab-confirmed detection of virus from swabs throughout the course of infection, including in those who were asymptomatic. However, the tests were less effective in picking up lower levels of virus at the very start and end of infection.
This is the first study that has been able to provide detailed data on the early phase of infection, before and during the appearance of symptoms. While there is a possibility of missing infectious virus early in the course of infection, particularly if only the nose is tested, the researchers say these findings overall support continued use of LFTs to identify people likely to be infectious.
The study provides supportive evidence that LFTs can reliably predict when someone is unlikely to infect others and can come out of isolation, and that twice-weekly rapid tests would allow diagnosis before 70-80% of viable virus was generated during the course of infection.
“We found that overall, lateral flow tests correlate very well with the presence of infectious virus,” said Professor Chiu. “Even though in the first day or two they may be less sensitive, if you use them correctly and repeatedly, and act on them if they read positive, this will have a major impact on interrupting viral spread.”
The authors highlight that while the model is a safe and effective approximation of real-world infection in young adults, the small sample size, reduced diversity of infected volunteers and limited follow up period may restrict the findings.
However, they add that despite these limitations, the study has important implications for public health, including around proper mask-wearing, isolation periods for infectious individuals, the use of LFTs, and establishing the human challenge platform to investigate further aspects of COVID-19.
Future work will see the team determine why some people became infected and others did not and develop a challenge virus using the Delta variant, which is already underway by Imperial in partnership with hVIVO and funded by the Wellcome Trust, and which could be used in follow-on trials.
According to the team, with these data supporting the safety of the infection challenge model and a Delta variant available, this could theoretically provide a ‘plug and play’ platform for testing new variants and therapies, including vaccines.
Professor Chiu added: “While there are differences in transmissibility due to the emergence of variants, such as Delta and Omicron, fundamentally, this is the same disease and the same factors will be responsible for protection against it.
“From the point of view of virus transmission related to the very high viral loads, we are likely if anything to be underestimating infectivity because we were using an older strain of the virus. With a newer strain, there might be differences in terms of size of response, but ultimately we expect our study to be fundamentally representative of this kind of infection.”
Professor Sir Jonathan Van-Tam, Deputy Chief Medical Officer for England, said: “Human challenge studies have been performed using other pathogens for decades, including flu and Respiratory Syncytial Virus (RSV). They need full independent ethical review and very careful planning – as has been the case this time. Every precaution is taken to minimise risk. “Scientifically these studies offer real advantage because the timing of exposure to the virus is always known exactly, therefore things like the interval between exposure and the profile of virus shedding can be accurately described. “This important study has provided further key data on COVID-19 and how it spreads, which is invaluable in learning more about this novel virus, so we can fine-tune our response. Challenge studies could still prove to be important in the future to speed the development of ‘next-generation’ Covid-19 vaccines and antiviral drugs. “These data underline just how useful a tool lateral flow tests can be to pick up people when infectious and the importance of wearing a face covering in crowded, enclosed spaces.”
Source: Imperial College London
From the Study referenced in the Article:
“All participants were inoculated with 10 TCID50 of SARS-CoV-2/human/GBR/484861/2020 (a D614G-containing pre-alpha wild-type virus; Genbank Accession number OM294022)”
May not be applicable to newer “Mutations” ( Omicron etc.,etc.). Laughable, as they refer to the Original SARS-2 CoV- 19 as “Wild type”. This shows the Academic Bias imposed on us…
COVID was “bred to spread” , even China has a very hard time controlling it…
There is NO virus. The only problem is controlling the “ignorance” and “indoctrination”.
As per Lord Schwab’s instructions, you’re due for your booster shots:
Even when they start doing what looks like legitimate scientific investigation, they STILL insist on spreading the BS propaganda surrounding face masks.
Face masks do nothing to prevent infection or transmission of an airborne virus. We already know this – about 150 peer-reviewed studies around the world have confirmed that wearing a face mask to stop a virus is akin to trying to keep a mosquito out with a chicken-wire fence.
So why does the learned Dr. Chiu pepper his conclusions with this BS?
Does Dr. Chiu lack the balls or backbone to face reality and go against the consensus of his bought-and-paid-for brethren? Is Dr. Chiu towing the line to keep his pension and his grant money?
Or is Dr. Chiu just as dumb and brainwashed as all the rest?
Either way, how can we have any confidence in Dr. Chiu’s work under these circumstances?
Just what snake-oil is Dr. Chiu really selling?
Whenever I broach the topic of the uselessness of masks, people will say, “well, it can’t hurt” or “it helps stop some of it.” Why they want to believe this, I don’t know—well, on second thought, it’s probably to avoid recognizing that they’ve fallen for a hoax and acted stupidly; few people want to acknowledge being made a fool of (as Mark Twain noted, it’s easier to fool someone than to convince them that they have been fooled.)
… and by the way, I can’t let it pass – look at that photograph of the two stupid fat f*ck public servant Gestapo wannabe’s marching up and down the footpath in the Australian concentration camp, all wrapped up in their “protective” uniforms and face shields, drunk on their new-found power to terrorise and abuse their supposed “Corona Chan” prisoners.
People like that – including those two stupid fat f*cks – are going to swing by the neck when the fat lady finally sings.
and their self-congratulatory smugness that they are “helping” humanity in crisis.
You can bet that ANYTHING from “Imperial[ist] College” has a nefarious agenda. They are wicked and satanic to the core.
There are no,,, as in zero, nada, zip,,, validated tests for the Sars 2 Cov virus or any of its supposed offshoots because they do not exist…
The PCR is not a test. The anti body tests will alarm on any cold virus.
Look,,, if they don’t isolate, purify the virus then how do they know what’s in ‘the drop’?
A lateral flow test is a fancy name for a rapid antigen and are absolute junk. You can pick them up on amazon for 25 bucks.
The most important aspect of this psyop is to keep you ‘believing’ the virus is real or the entire shitshow implodes including the Wuhan release bs being propagated night and day.
Come on,,, Does anyone believe the Klaus Schwabs of the world would release a bug so bad that it could do them in as well! The parasites are powersites,,, they are not stupid! There is no such thing as an antidote or 100% effective vaccine in bug world. No,,, the bio weapon is the shots. As we see,,, those are easily controlled.
And Imperial College. They started the covid scam with the fake model showing millions were going to die. They are flimflam artists!
This test is bogus. NEVER has anyone isolated the so called “virus”. Whatever they are dripping into the participants noses, cannot be a “virus”. How about someone gwt a sample of this “virus” and look at it under an electron microscope to see exactly what they are introducing to the test subjects? 1.5 million Euro’s says it’s NOT a virus:
Where is the virus:
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We cannot guarantee that your gene 144 won’t be deleted, your X / Y Chromosome won’t be inverted, your gene 69-70 won’t be deleted or mutated, that you may experience loss-of-function due to protein folding, that your gene E1, E3, E4 won’t be deleted, that you won’t receive shots full of magnetic graphene oxides, nano-biosensors and self-integrated bio-circuits (motherboards, transistors, routers, antennas, etc…).
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Can’t we just proceed with apprehending Gates, Fauci, Schwab and a few other miscreants, namely former and current ‘heads of state’, have a quick trial, then take them behind the nearest barn for instant execution?
CEOs of Moderna, Pfizer, AstraZeneca and J&J must be included, or full justice will not have been served.
Ladies and Gentlemen,
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Please renew your quarterly booster subscriptions to protect yourself, your pets and your family from the upcoming iDelta variant (We apologize for running out of the alphabet letters for the new variants – vaccines are breeding more variants than originally thought).
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end all mandates ottowa canada https://www.paulcraigroberts.org/2022/02/03/all-of-canada-has-joined-the-convoy-except-trudeau-who-accuses-freedom-convoy-2022-of-propagating-hatred-racism-and-violence/ drone view https://www.youtube.com/watch?v=nFBGlhS4xBY
more nonsense from the ground zero of ‘covid’ propaganda…
reinforcing all the meaningless diktats, like mask wearing, viral load and the useless lateral flow test… not forgetting the fake microsoft coff itself… the common cold…
Lysenko like drivel, liberally salted with ‘trust the scientism’… all reassuringly delivered by the same miscreants who pulled the pandemic heist out of their arse, their pockets bulging with bill gates cash.. and copies of klaus schwabs dreary tome … the great reset..
criminals all of them..